目的 基于网络药理学探讨三生合欢饮治疗脂代谢相关抑郁症的分子机制。方法 从数据库筛选三生合欢饮作用靶基因及脂代谢相关抑郁症靶基因，构建“复方中药-活性成分-关键靶点”网络、蛋白相互作用网络，进行GO和KEGG富集分析。结果 三生合欢饮靶基因911个，疾病靶基因9017个，交集得724个共有靶基因。PPI筛选出21个核心基因，包括PTGS2、HSP90AA1、ESR1等。GO条目11307条，涉及蛋白质磷酸化、细胞对脂质反应等BP，膜筏、树突等CC，蛋白激酶活性等MF。KEGG富集于癌症通路、脂质与动脉粥样硬化等313条通路。结论 三生合欢饮通过多靶点、多成分、多条信号通路治疗脂代谢相关抑郁症。

Objective To investigate the molecular mechanism of Sansheng Hehuan Yin in treating lipid metabolism-related depression based on network pharmacology. Methods Target genes of Sansheng Hehuan Yin and those related to lipid metabolism-related depression were screened from databases. A “Chinese herbal compound-active ingredient-key target” network and a protein-protein interaction network were constructed, followed by GO and KEGG enrichment analyses. Results A total of 911 target genes of Sansheng Hehuan Yin and 9,017 disease-related target genes were identified, yielding 724 overlapping targets. Twenty-one core genes, including PTGS2, HSP90AA1, and ESR1, were screened from the PPI network. A total of 11,307 GO entries were enriched, involving biological processes such as protein phosphorylation and cellular response to lipid, cellular components such as membrane raft and dendrite, and molecular functions such as protein kinase activity. KEGG enrichment analysis identified 313 signaling pathways, including pathways in cancer, lipid and atherosclerosis, among others. Conclusion Sansheng Hehuan Yin may exert its therapeutic effects on lipid metabolism-related depression through multiple targets, components, and signaling pathways.